Established in : 1965
 

MANDATE

• To undertake epidemiological surveys of industrial and agricultural workers.
• To generate toxicological data for various industrial and chemicals and safety assessment of various chemicals and products.
• To develop suitable diagnostic tests for early diagnosis of toxicity and to suggest remedial and preventative measures.
• To develop sensitive methods for estimation of toxic chemicals.
• To provide expert consultancy, guidance to government agencies/industries on potential risk and toxicological matters.
• To interact with international organizations such as WHO, FAO, UNEP, UNDP, IRPTC, IPCS, as national correspondent on toxicological matters.

MAIN FACILITIES

• Facilities for safety evaluation of chemicals and materials using standard US FDA & EPA, OECD guidelines following Good Laboratory Practices.
• Animal House (animal breeding and maintenance facilities).
• Toxicology Information Centre: computerized database, technical query-answer services.
• State of art instrumentation facilities for analysis of pollutants and toxicants.
• Wastewater analysis laboratory.
• Environmental monitoring, Enviromental Impact Analysis.

SIGNIFICANT ACHIEVEMENTS                          

• Mechanisms by which pesticides, heavy metals, monomers, plasticizers, and other plastic additives, solvents, food color and dye intermediates, industrial dust and other chemical cause deleterious effects have been elucidated.
• Methods of early diagnosis of manganese poisoning, a peripheral model for monitoring the neurological disorders caused by neurotoxic diseases has been developed.
• Specific animal models have been developed for studying the mechanisms of carcinogenesis, prevention of toxicity of chemicals using immunomodulators and nutrient supplements and drugs have been developed.
• Demonstrated ability of some chelating agents in abrogating the toxicity due to metals in animal models. Vitamin B complex supplementation has been found to diminish susceptibility to lead and cadmium intoxication.
• Protocols for ecotoxicological evaluation of effluents using biological species, safety evaluation of plastics and polymers and screening of the reproductive, immunotoxic, neurotoxic, genotoxic, phytotoxic, photo toxic and carcinogenic and mutagenic effects of chemicals have been developed.
• Toxicity data on the widely used chemicals of interest to country have been generated.
• Monographs , handbooks, criteria documents, guidelines and manuals on toxicity of chemicals has been published.
• The Centre has contributed significantly to Drinking Water Mission, Ganga Action Plan, Global Climatic Change Programme and All India Co-ordinated Programmes on Pesticides and Metal Exposure Assessment.
• Programme on pesticides and Metal Exposure Assessment. National Standards for consumer safety protection and test protocols for detergents have been developed

PUBLICATIONS

PATENTS                   10

TECHNOLOGIES

DIRECTOR
Dr. P. K. Seth

CONTACT ADDRESS
Mahatma Gandhi Marg, Post Box No. 80, Lucknow, 226 001.
Telephone: (091)522-228227, 221856
Telegram : INTOXI, LUCKNOW.
Telex    : 0535-456 ITRC IN.
Fax      : (091)522-228227, 228471.
E-mail   : intoxi@itrc.sirnetd.ernet.in.

Copyright(c) Industrial Toxicology Research Institute, Lucknow, 1998.
Created and hosted by NIO, Goa.